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Canine Hereditary Nephritis (HN) is a group of inherited glomerular diseases of collagen type IV, which often progress to renal failure.
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General information
Canine Hereditary Nephritis (HN) is a group of inherited glomerular diseases of collagen type IV, which often progress to renal failure. X-linked nephritis is caused by mutations in the alpha 5 chain of collagen type IV (COL4A5).
Clinical features
Clinical signs include for the male affected Samoyed proteinuria and the dogs develop rapidly progressive renal failure. The symptoms are usually fatal before 1 year of age. Approximately 31% of the carrier female Samoyeds developed mild renal disease, and 38% progressed to the final stage of the renal disease.
Additional information
References
Pubmed ID: 8171024
Omia ID: 1112
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