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X-Linked Myotubular Myopathy (XLMTM) in the Rottweiler is a recently-discovered variant of a severe muscle disorder that often requires euthanasia.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
X-Linked Myotubular Myopathy (XLMTM) in the Rottweiler is a recently-discovered variant of a severe muscle disorder that often requires euthanasia. This variant, caused by an X-linked recessive mutation to the gene MTM1, has as of yet only been observed in Australian Rottweilers. Related variants have been observed in the Labrador Retriever and the Boykin Spaniel.
Clinical features
Affected puppies typically start displaying poor muscle growth and progressive weakness between 7 and 13 weeks of age. They behave and eat normally, but tire easily and have difficulty raising their heads or standing. Cold and stress worsen symptoms, which also increase in severity over time. Affected dogs are typically euthanized on humane grounds.
Additional information
References
Pubmed ID: 25664165
Omia ID: 1508