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Golden Retriever Muscular Dystrophy (GRMD) is a form of the X-linked muscle disorder Duchenne Muscular Dystrophy (DMD) specific to the Golden Retriever.
10 working days
Swab, Blood EDTA, Blood Heparin, Semen, Tissue
|Mode of Inheritance|
|Also known as||
DD-MD, X-linked muscular dystrophy; Dystrophin-deficient muscular dystrophy, DMD
Golden Retriever Muscular Dystrophy (GRMD) is a form of the X-linked muscle disorder Duchenne Muscular Dystrophy (DMD) specific to the Golden Retriever. The disorder is severe and ultimately fatal, and causes progressive degradation of the dog’s muscles. Like other forms of DMD, this variant is caused by an X-linked recessive mutation to the DMD gene.
Clinical signs are shuffling gait or shortened stride, inability to completely open the jaw, difficulty eating, thickening of the base of the tongue, excessive salivation, abduction of front paws, adduction of stifles and hocks, and prominent wasting of temporal and trunk muscles. Signs start presentation at approximately 8 weeks of age, and are ultimately fatal.
Pubmed ID: 1577476
Omia ID: 1081