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Multidrug resistance 1 (MDR1), also called Ivermectin Sensitivity, is a defect in the blood-brain barrier that can cause an adverse reaction to certain drugs.
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Specifications
| Breeds | Smooth Collie, Australian Shepherd, Border Collie, German Shepherd, Old English Sheepdog, Rough Collie, Shetland Sheepdog, Whippet |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Multidrug resistance 1 (MDR1), also called Ivermectin Sensitivity, is a defect in the blood-brain barrier that can cause an adverse reaction to certain drugs. It is caused by a mostly recessive mutation to the ABCB1 (MDR1) gene.
Clinical features
Neurotoxicity following drug administration, which varies according to dose, is the main sign. Dogs may show ataxia, tremors, seizures, excessive salivation, obtundation, bradycardia, mydriasis, loss of menace, loss of papillary light responses, coma and respiratory arrest.
Additional information
This test is based on an association study.
This disorder is noted as recessive. However, in some cases, carriers of the mutation have been observed to present with a milder form of the disorder.
References
Pubmed ID: 11692082
Omia ID: 1402
Year published:
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