€57,48 €47,50 excl. VAT
Multidrug Resistance 1 (MDR1), sometimes known as Ivermectin Sensitivity, is a disorder that affects the blood-brain barrier.
10 working days
€5,95 shipping and administration per order (incl. VAT)
Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Multidrug Resistance 1 (MDR1), sometimes known as Ivermectin Sensitivity, is a disorder that affects the blood-brain barrier. As a result, affected animals can be in effect poisoned when given certain drugs as part of standard veterinary procedures. In cats, a variant of the disease is caused by a recessive mutation to the gene ABCB1.
It is estimated that this mutation occurs in approximately 4% of domestic cats.
Clinical features
Affected cats are likely to experience adverse reactions (central nervous system toxicity) to P-glycoprotein substrate drugs such as ivermectin, imidacloprid and selamectin.
Additional information
References
Pubmed ID: 25660379
Omia ID: 1402
Related products
-
- Australian Shepherd, German Shorthaired Pointer
- CLN8
- Nervous system
-
- All Breeds
- None
-
- All Breeds
- MITF
- Integumentary system
-
- Cairn Terrier, Scottish Terrier, West Highland White Terrier
- SLC37A2
- Skeletal system
