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H746

Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle elicited upon exposure to inhalation anesthetics and depolarizing muscle relaxants.

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Specifications

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle elicited upon exposure to inhalation anesthetics and depolarizing muscle relaxants. It is considered to be a clinical syndrome rather than a single disease because multiple environmental and genetic factors cause a complex of events. MH has also been reported in humans, pigs, cats and horses.

Clinical features

MH-susceptible (MHS) dogs show no clinical signs until exposed to inhalation anesthetics and depolarizing muscle relaxants. When exposed, MHS dogs show tachycardia, hyperthermia, elevated CO2 levels and eventually death if the used anesthetic is not discontinued.

Additional information

References

Pubmed ID: 11575546, 15474681

Omia ID: 621

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