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H641

Laryngeal Paralysis (LP) is a disorder of the throat in which the cartilages of the larynx no longer properly function, impeding both breathing and swallowing.

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Specifications

Breeds

,

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Laryngeal Paralysis (LP) is a disorder of the throat in which the cartilages of the larynx no longer properly function, impeding both breathing and swallowing. This specific form of the disorder, found in the Miniature Bull Terrier, has been linked to a mutation on the gene RAPGEF6.

Clinical features

Signs of laryngeal paralysis in dogs vary, but generally include respiratory distress, intolerance to exercise and possibly an impaired or altered voice. Episodes of serious breathing difficulties can potentially be life-threatening, and surgical intervention such as a tracheostomy may be required to provide relief.

Additional information

The mutation in this test should be considered a risk factor. It is associated with the disorder, but does not necessarily guarantee it.

Hereditary LP is also associated with other neurological disorders.

References

Pubmed ID: 31647804

Omia ID: 2222

How does it work?

1. Select your product(s)

Select your single test, a CombiBreed Package or create your own Bundle.

2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

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