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P655

Incontinentia Pigmenti (IP) is a skin and tissue disorder that causes the development of skin lesions and and possibly abnormalities of the teeth, hooves and eyes in affected mares.

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Specifications

Breeds

,

Gene

Organ

specimen

Hair, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Incontinentia Pigmenti (IP) is a skin and tissue disorder that causes the development of skin lesions and and possibly abnormalities of the teeth, hooves and eyes in affected mares. The disorder is found in the Quarter Horse, and is caused by an X-linked dominant mutation to the gene IKBKG

Clinical features

Affected mares develop itchy, exudative lesions on the skin soon after birth. These lesions can evolve into wart-like lesions and areas of alopecia (hair loss). Occasionally, hair re-growth with a woolly appearance is observed. Affected horses also have streaks of darker and lighter coat colouration from birth, which can resemble a brindled coat pattern.

IP only develops in carrier females. Males carrying the mutation die in utero. This means that in breeding, carrier females have only a 33% chance of giving birth to a stallion, rather than 50%.

Additional information

References

Pubmed ID: 24324710

Omia ID: 1899

How does it work?

1. Select your product(s)

Select your single test, a CombiBreed Package or create your own Bundle.

2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

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