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H378

Ichthyosis is a disease of the skin, causing itch, hair loss and the formation of dry, flaky “scales”.

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Specifications

Breeds

,

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Ichthyosis is a disease of the skin, causing itch, hair loss and the formation of dry, flaky “scales”. It also leaves the skin vulnerable to fungal infection. This variant of the disorder, known as Autosomal Recessive Congenital Ichthyosis (ARCI) is found in the American Bulldog and American Bully. It is caused by a recessive mutation to the gene NIPAL4.

Clinical features

Affected puppies present within the first few weeks after birth with dishevelled coats, white or brown scaling and reddened skin with brown discolorations. The condition may worsen slightly as the dog grows to adulthood, and may be complicated by fungal infection by e.g. Malassezia yeast. Malassezia infection can in turn cause an unpleasant odour.

Additional information

This test only detects one mutation therefore a dog can still develop ichthyosis from other mutations.

References

Pubmed ID: 28122049

Omia ID: 1980

How does it work?

1. Select your product(s)

Select your single test, a CombiBreed Package or create your own Bundle.

2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

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