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Hereditary Footpad Hyperkeratosis (HFH) is a skin disorder of the footpads, which causes the development of thick, painful, callus-like growths.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Hereditary Footpad Hyperkeratosis (HFH) is a skin disorder of the footpads, which causes the development of thick, painful, callus-like growths. This variant of the disease, known as Palmoplantar Hyperkeratosis or Digital Hyperkeratosis (DH), is found in the Irish Terrier and Kromfohrländer. It is caused by a recessive mutation to the gene FAM83G.
Clinical features
HFH initially leads to thickened and hardened footpads. It involves all footpads and is noticed at 4–5 months of age. Subsequently, the inelastic pad surface develops cracks and fissures, which predispose affected dogs to secondary infections. The nails of affected dogs are very hard and seem to grow faster. Affected animals avoid walking on irregular surfaces and if not properly managed, HFH can lead to considerable pain and lameness.
Additional information
References
Pubmed ID: 24832243
Omia ID: 1327
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