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P705

Hyperkalemic Periodic Paralysis (HYPP) in horses is caused by a mutation in the muscle’s sodium channel gene.

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Specifications

Breeds

Gene

Organ

specimen

Hair, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Hyperkalemic Periodic Paralysis (HYPP) in horses is caused by a mutation in the muscle’s sodium channel gene. As a result the, muscles contract involuntarily with blood potassium changes. This can occur with stress or fasting followed by eating high potassium feed like alfalfa.

The disorder is caused by an incompletely penetrant dominant mutation to the gene SCN4A. It occurs primarily in the Quarter Horse.

Clinical features

Horses affected by HYPP have severe muscle problems following exercise. They show episodes of muscle twitching and shaking. The signs usually begin by two to three years of age. Severely affected horses may have a hard time swallowing or make loud breathing noises. Sometimes sudden death can occur following a severe episode.

Additional information

Even horses which are heterozygous may show symptoms of the disease. HYPP horses may appear normal between episodes.

References

Pubmed ID: 1338908

Omia ID: 785

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2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

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