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P705

Hyperkalemic periodic paralysis (Hypp) is caused by a mutation in the muscle’s sodium channel gene.

10 working days

Specifications

Breeds

Gene

Organ

specimen

Hair, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Hyperkalemic periodic paralysis (Hypp) is caused by a mutation in the muscle’s sodium channel gene. As a result the muscles contract involuntarily with blood potassium changes. This can occur with stress or fasting followed by eating high potassium feed like alfalfa.

Clinical features

Horses affected by HYPP have severe muscle problems following exercise. They show episodes of muscle twitching and shaking. The signs usually begin by two to three years of age. Severely affected horses may have a hard time swallowing or make loud breathing noises. Sometimes sudden death can occur following a severe episode.

Additional information

Even horses which are heterozygous may show symptoms of the disease. HYPP horses may appear normal between episodes.

References

Pubmed ID: 1338908

Omia ID: 785

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