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Hereditary Footpad Hyperkeratosis (HFH) is a skin disorder of the footpads, which causes the development of thick, painful, callus-like growths.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Hereditary Footpad Hyperkeratosis (HFH) is a skin disorder of the footpads, which causes the development of thick, painful, callus-like growths. This variant of the disorder, found in the Rottweiler, is caused by a recessive mutation to the gene DSG1. The disorder is also known as Palmoplantar Hyperkeratosis.
Clinical features
Symptoms for HFH affected dogs start at about 8 weeks of age, with footpads appearing unusually dry. The pads develop thick, rapidly-growing horny growths, which are painful and can cause additional discomfort while standing. The condition may also leave the dog more susceptible to additional skin and ear infections.
Additional information
References
Pubmed ID: 32344723
Omia ID: 2266