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Hereditary Equine Regional Dermal Asthenia (HERDA), also known as Hyperelastosis Cutis (HC) is a tissue disorder in the American Quarter Horse that causes loose, fragile skin.

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Specifications

Breeds

Gene

Organ

specimen

Hair, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Hereditary Equine Regional Dermal Asthenia (HERDA), also known as Hyperelastosis Cutis (HC) is a tissue disorder in the American Quarter Horse that causes loose, fragile skin. The disorder is caused by a recessive mutation to the gene PPIB.

Clinical features

The primary symptom of HERDA is loose skin that can be described as stretchy or elastic. The skin is more fragile than normal, sloughing easily and causing ulcers, hematomas and scarring. The symptoms usually become apparent between 1 and 2 years of age, when the horse starts its saddle training. Owners typically elect for euthanasia.

Additional information

References

Pubmed ID: 17498917

Omia ID: 327

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