Haemophilia A – Old English Sheepdog

Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs. Caused by an X-linked recessive mutation to the gene F8, the disease strongly impairs the blood’s ability to clot, which can lead to severe symptoms such as spontaneous internal bleeding, or uncontrolled bleeding after injury or surgery. The specific variant of the disease analysed in this test occurs in the Old English Sheepdog. Related variants are also found in the Irish Setter and Miniature Schnauzer, Boxer, German Shepherd, and the Rhodesian Ridgeback.