€57,48 €47,50 excl. VAT
Progressive Retinal Atrophy (PRA) is a large group of genetic diseases in which the retina gradually degenerates over time, causing a progressive loss of vision.
10 working days
€5,95 shipping and administration per order (incl. VAT)
Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Progressive Retinal Atrophy (PRA) is a large group of genetic diseases in which the retina gradually degenerates over time, causing a progressive loss of vision. This early-onset variant of the disease, known as gPRA or gPRA^SPD, is found in the Schapendoes. It is caused by a recessive mutation to the gene CCDC66. A related variant of gPRA is also found in the Portuguese Water Dog.
Clinical features
Affected Schapendoes dogs appear normal when young, but develop gPRA at an age of onset between 2-5 years. Early in the disease, affected dogs are night-blind, lacking the ability to adjust their vision to dim light; later, their daytime vision also fails. This process of complete photoreceptor degeneration takes up to 2 years.
Additional information
References
Pubmed ID: 19777273
Omia ID: 1521
Related products
-
- Australian Shepherd, German Shorthaired Pointer
- CLN8
- Nervous system
-
- Parson Russell Terrier, Jack Russell Terrier
- CAPN1
- Nervous system
-
- Labrador Retriever
- LOC489707
- Sensory organs
-
- All Breeds
- None
