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Foal immunodeficiency syndrome (FIS) is a recessive disease leading to B-lymphocyte immunodeficiency and progressive anemia.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Hair, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Foal immunodeficiency syndrome (FIS) is a recessive disease leading to B-lymphocyte immunodeficiency and progressive anemia. The disease is caused by a mutation in the sodium/myo-inositol cotransporter gene (SLC5A3). Affected foals develop a non-hemolytic, non-regenerative progressive anemia, which is enough to cause death.
Clinical features
Clinical features are progressive and include anemia, lethargy, reduced appetite, weakness, diarrhea and poor growth.
Additional information
References
Pubmed ID: 21750681
Omia ID: 1578