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Exercise-induced collapse (EIC) is an autosomal, recessive neuromuscular disorder.

25 working days



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Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance


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Year Published

General information

Exercise-induced collapse (EIC) is an autosomal, recessive neuromuscular disorder. The disorder is caused by a mutation in the dynamin 1 (DNMI1) gene, which causes an substitution in a highly conserved region of the protein. The dynamin 1 protein is functional in neurotransmission and synaptic vesicle endocytosis.

Clinical features

Clinical features are characterised by muscle weakness and life-threatening collapse after intense excercise. Collapse episodes generally last for 10 minutes and the dogs fully recover mostly after 30 minutes. Occasionally are the symptoms fatal.

Additional information

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Pubmed ID: 18806795

Omia ID: 1466

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