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P306

Chondrodysplastic Dwarfism is a skeletal disorder that causes reduced growth and an abnormal body shape.

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Specifications

General information

Chondrodysplastic Dwarfism is a skeletal disorder that causes reduced growth and an abnormal body shape. This variant of dwarfism, found in the Miniature Horse, can be caused by any combination of four different recessive mutations to the gene ACAN, which are known as D1, D2, D3* and D4. The D3* mutation is also known to occur in the Shetland Pony. ACAN-caused dwarfism is severe and painful, and in severe cases may require euthanasia of an affected foal.

Clinical features

Horses affected by chondrodysplastic dwarfism are extremely short relative to their age. They generally have have disproportionately short limbs and necks, bowed forelegs, a compressed face with bulging eyes, a severe underbite, a cleft palate, a protruding tongue and hernia of the abdomen. Affected foals may spontaneously abort during pregnancy, or else require euthanasia soon after birth due to severely reduced quality of life.

In addition, carriers of these mutations may be shorter than normal.

Additional information

This test series does not cover all possible causes for dwarfism and skeletal dysplasia in horses.

References

Pubmed ID: 2794904

Omia ID: 1271

How does it work?

1. Select your product(s)

Select your single test, a CombiBreed Package or create your own Bundle.

2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

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