€57,48 €47,50 excl. VAT
Progressive Retinal Atrophy (PRA) is a large group of genetic diseases in which the retina gradually degenerates over time, causing a progressive loss of vision.
10 working days
Swab, Blood EDTA, Blood Heparin, Semen, Tissue
|Mode of Inheritance|
|Also known as|
Progressive Retinal Atrophy (PRA) is a large group of genetic diseases in which the retina gradually degenerates over time, causing a progressive loss of vision. This variant of PRA, Autosomal Dominant Progressive Retinal Atrophy, is found in the English Mastiff. It is caused by a dominant mutation to the gene RHO.
Dominant PRA is an eye disorder that causes the rod and cone cells to deteriorate over time, eventually leading to complete blindness. Affected dogs often appear to have clinically normal eyes until about 2-3 years of age, when cells begin to die and vision loss increases. Some puppies show signs of night-blindness at 6 weeks old. Most affected dogs are completely blind at the age of 3-4 years.
Pubmed ID: 11972042
Omia ID: 1346