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A recessive mutation to the keratin gene KRT71 is responsible for the growth of a curly rather than straight coat in certain dogs.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Year Published |
General information
A recessive mutation to the keratin gene KRT71 is responsible for the growth of a curly rather than straight coat in certain dogs. The variant analysed in this test, designated as c^1, is found in the Portuguese Water Dog. A related variant, c^2, has been observed in the Bichon Frise, Chesapeake Bay Retriever, Curly-coated Retriever, Irish Terrier, Lagotto Romagnolo and Spanish Water Dog.
Clinical features
Affected dogs have a curly-haired coat instead of waivy haired. Coats must be of sufficient length to curl in the first place.
Dogs carrying the FGF5 mutation with the RSPO2 insertion, have furnishings and long soft coats, rather than wiry ones. When dogs carry variants in both FGF5 and KRT71, long and curly coat is seen.
If all three mutations (KRT71, FG5 en RSPO2) are present, the phenotype is long and curly with furnishings.
Additional information
References
Pubmed ID: 19713490
Omia ID: 245
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