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H921

A recessive mutation to the keratin gene KRT71 is responsible for the growth of a curly rather than straight coat in certain dogs.

10 working days

Specifications

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue
Mode of Inheritance

Chromosome

Year Published

General information

A recessive mutation to the keratin gene KRT71 is responsible for the growth of a curly rather than straight coat in certain dogs. The variant analysed in this test, designated as c^1, is found in the Portuguese Water Dog. A related variant, c^2, has been observed in the Bichon Frise, Chesapeake Bay Retriever, Curly-coated Retriever, Irish Terrier, Lagotto Romagnolo and Spanish Water Dog.

Clinical features

Affected dogs have a curly-haired coat instead of waivy haired. Coats must be of sufficient length to curl in the first place.

Dogs carrying the FGF5 mutation with the RSPO2 insertion, have furnishings and long soft coats, rather than wiry ones. When dogs carry variants in both FGF5 and KRT71, long and curly coat is seen.

If all three mutations (KRT71, FG5 en RSPO2) are present, the phenotype is long and curly with furnishings.

Additional information

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References

Pubmed ID: 19713490

Omia ID: 245

How does it work?

1. Select your product(s)

Select your single test, a CombiBreed Package or create your own Bundle.

2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

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