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Cone-Rod Dystrophy (CRD) is a disorder of the photoreceptor cells of the eye, which can lead to early-onset blindness in affected dogs.
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Cone-Rod Dystrophy (CRD) is a disorder of the photoreceptor cells of the eye, which can lead to early-onset blindness in affected dogs. This variant of the disorder, Cone-Rod Dystrophy, Type 2 (crd2) is found in the American Pit Bull Terrier. It is caused by a recessive mutation to the gene IQCB1. A similar variant of the disease, called crd1, occurs in the American Staffordshire Terrier.
Affected dogs have progressively degenerating retinas, which grow thinner and more “ragged” within the first few months after birth. They will display severe vision impairment in both well-lit and dimly-lit conditions, which can progress to more severe blindness within the first year of age.
Pubmed ID: 24045995
Omia ID: 1675