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Craniomandibular Osteopathy (CMO), also known as Lion Jaw, is a developmental bone disorder that causes bony lesions on the skull.
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Specifications
| Breeds | Cairn Terrier, Scottish Terrier, West Highland White Terrier |
|---|---|
| Gene | |
| Chromosome | 5 |
| Mutation | c.1332C>T |
| Organ | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Dominant with Incomplete Penetrance |
| Also known as | CMO |
General information
Craniomandibular Osteopathy (CMO), also known as Lion Jaw, is a developmental bone disorder that causes bony lesions on the skull. Occurring in West Highland White Terriers, Scottish Terriers and Cairn Terriers, it is caused by a dominant mutation with incomplete penetrance to the Solute Carrier Family 37 Member 2 (SLC37A2) gene.
Because of its occurance in the West Highland White Terrier, the disorder is also known as Westie Jaw.
A closely related variant of the disorder is found in the Basset Hound.
Clinical features
CMO begins manifesting in affected dogs between 4 and 8 months of age. Signs include swelling of the jaw, difficulty opening the jaw, pain, a lack of apetite and periodic fever. Bony lesions develop on the skull, mainly on the jawbone. Symptoms usually recede when the dog has finished its growth period.
Additional information
References
Pubmed ID: 27187611
Year published: 2016
Omia ID: 2244
Omia variant ID: