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Copper Toxicosis, otherwise known as Wilson Disease, is a complex genetic disease that occurs in several different dog breeds.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Copper Toxicosis, otherwise known as Wilson Disease, is a complex genetic disease that occurs in several different dog breeds. A dog that retains too much copper from its diet suffers from copper toxicosis, which causes liver damage and associated negative effects.
In the Bedlington Terrier, a recessive mutation to the gene COMMD1 (also known as MURR1) is known to cause elevated copper levels, resulting in copper toxicosis.
While copper toxicosis also occurs in breeds such as the Doberman and Labrador Retriever, the disorder in those breeds is caused by a mutation to another gene, ATP7B.
Clinical features
Clinical signs of liver damage as a result of copper toxicosis can include an inflamed liver, anorexia, vomiting, lethargy, weight loss, jaundice and a swollen abdomen.
Copper toxicosis can be mitigated with a low-copper, high-zinc specialized diet.
Additional information
With the current reports it cannot be stated that the deletion in the COMMD1 gene is the only cause of copper toxicosis.
References
Pubmed ID: 16293123
Omia ID: 1988