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The Silver gene (SILV gene), also called premelanosome protein (PMEL17 gene) is responsible for Merle.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Chromosome | 10 |
| Organ | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Incomplete Dominant |
| Also known as | M-Locus |
General information
The Silver gene (SILV gene), also called premelanosome protein (PMEL17 gene) is responsible for Merle. This gene is also known as M-Locus. Merle only dilutes eumelanin (black) pigment; dogs with two copies of the allele e (homozygous e/e) at E-Locus have no black pigment, thus do not express merle. Merle is an incompletely dominant coat colour pattern characterised by irregularly shaped patches of diluted pigment and solid colour.
Clinical features
The M-locus determines the merle pattern in dogs and consists of several variants (different SINE lengths) that influence how strongly the pattern is expressed. Dogs with the N/N (wild-type) variant do not carry the merle gene and show no merle pattern. Cryptic merle (Mc) dogs are genetically merle but usually show little to no visible merling, meaning they may easily be mistaken for non-merle dogs. A transitional form, known as cryptic merle+ (Mc+), may show very subtle merle markings.
Atypical merle (Ma) causes a slight dilution of the coat colour, while atypical merle+ (Ma+) results in stronger dilution and may appear more merle-like. Classic merle (M) produces a clearly visible merle pattern, often accompanied by blue or partially blue eyes. The strongest expression, harlequin merle (Mh), leads to extensive dilution with white patches and is associated with an increased risk of hearing and eye-related health issues.
Additional information
This test is performed by an external laboratory. CombiBreed takes care of the mediation between you as a customer and the external laboratory. In this case, CombiBreed cannot be held liable for the behaviour of the client and/or contractor.
References
Pubmed ID: 30235206
Year published: 2018
Omia ID: 211
Omia variant ID: