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The Extension gene (MCR1 gene) controls the production of black and red pigment.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
The Extension gene (MCR1 gene) controls the production of black and red pigment. The Extension (E) locus represents the melanocortin 1 receptor (MC1R). One allele at the E locus called E^M causing a black mask on the dogs face. The black mask is known as melanistic mask and causes a black-based coat.
Clinical features
The melanistic mask is only visible on dogs with a fawn or brindle coat. On the muzzle and occasionally the ears the mask can appear as black, liver, blue or isabella. Dogs with a black, brown or blue coat do not have a mask that is distinguishable from their original coat.
Additional information
References
Pubmed ID: 12692165
Omia ID: 1590