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The Extension gene (MCR1 gene) controls the production of black and red pigment.
12 working days
Swab, Blood EDTA, Blood Heparin, Semen, Tissue
|Mode of Inheritance|
The Extension gene (MCR1 gene) controls the production of black and red pigment. The Coat Colour E locus, extension test tests for the genetic status of the E-locus. The E-locus has two variants (alleles). It is presumed that (almost) all cats are fixed for the dominant allele E, they have two copies of the dominant allele E and based on this gene alone could produce both red and and black pigment.
The recessive allele E results in kittens that are born with a black/brown tabby pattern (blue/apricot in dilute cats). As the kittens mature, the black/blue pigment is replaced by yellow resulting in the golden coat coloration seen in adult cats. Originally it was named X Colour, now it is called Amber.
Cats with two copies of the allele e only have the Amber Coat Colour when the dominant O allele at the O-locus is not present.
Pubmed ID: 19422360
Omia ID: 1199