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Amber (previously called X-Colour) is a yellow recessive coat colour observed in the Norwegian Forest Cat (NFC) population and apparently absent in other cat breeds.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Chromosome | E2 |
| Mutation | c.250G>A |
| Organ | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | E-Locus |
General information
Amber (previously called X-Colour) is a yellow recessive coat colour observed in the Norwegian Forest Cat (NFC) population and apparently absent in other cat breeds. The colour is caused by a single MC1R allele on a locus called e. In general, the extension (E) locus MC1R interacts with the agouti locus to produce black and reddish pigments. The E-locus has two variants (alleles). It is presumed that (almost) all cats have two copies of the dominant allele E, meaning they can produce both red and and black pigment. If this is not the case, Amber coat colour can arise.
Clinical features
The recessive allele E results in kittens that are born with a black/brown tabby pattern (blue/apricot in dilute cats). As the kittens mature, the black/blue pigment is replaced by yellow resulting in the golden coat colouration seen in adult cats.
Additional information
Cats with two copies of the allele e only have the Amber Coat Colour when the dominant O allele at the O-locus is not present.
References
Pubmed ID: 19422360
Year published: 2009
Omia ID: 1199
Omia variant ID: