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H897

Coat colour in dogs is controlled by a wide range of different genes working together.

10 working days

€5,95 shipping and administration per order (incl. VAT)

Specifications

Breeds

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Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Coat colour in dogs is controlled by a wide range of different genes working together. These genes are often referred to as ‘loci’. The Dilution, or D-Locus, corresponds to the gene for melanophilin, MLPH, which is involved in the distribution of pigment. Mutations of the D-Locus result in a ‘dilution’ of dark coat colours, turning them lighter and more silvery.

Any combination of two mutant alleles will result in a diluted coat. This variant of the D-Locus mutation, designated as d^3, is found in breeds such as the Chihuahua, Hungarian Mudi and Hungarian Pumi, Italian Greyhound and Shih-Tzu.

Clinical features

Hair and nose colour are diluted, the eye colour lightens to amber. The allele D is dominant and does not have an effect on the coat colour. Only in dogs with two copies of a recessive allele d, the coat colour is diluted. Black dilutes into grey, also called blue or charcoal. The coat ranges from silver to almost black, but all have a blue nose. Chocolate/brown/liver dilutes into lilac/light tan/Isabella, their noses vary from pink, liver to isabella. Red/yellow/cream dilutes into champagne.

Additional information

Coat colour is an intricate trait that involves a combination of multiple different genes. Testing for a range of different loci will give the most complete prediction of a dog's coat colour genetics.

Additional, undiscovered variants of the D-Locus mutation are likely to exist.

References

Pubmed ID: 32531980

Omia ID: 31

How does it work?

1. Select your product(s)

Select your single test, a CombiBreed Package or create your own Bundle.

2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

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