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Coat colour in dogs is controlled by a wide range of different genes working together.
10 working days
Mudi, Pumi, Chihuahua, Greyhound, Italian Greyhound, Mastiff, Pekingese, Shetland Sheepdog, Shih-Tzu, Tibetan Mastiff, Yorkshire Terrier
Swab, Blood EDTA, Blood Heparin, Semen, Tissue
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Coat colour in dogs is controlled by a wide range of different genes working together. These genes are often referred to as ‘loci’. The Dilution, or D-Locus, corresponds to the gene for melanophilin, MLPH, which is involved in the distribution of pigment. Mutations of the D-Locus result in a ‘dilution’ of dark coat colours, turning them lighter and more silvery.
Any combination of two mutant alleles will result in a diluted coat. This variant of the D-Locus mutation, designated as d^3, is found in breeds such as the Chihuahua, Hungarian Mudi and Hungarian Pumi, Italian Greyhound and Shih-Tzu.
Hair and nose colour are diluted, the eye colour lightens to amber. The allele D is dominant and does not have an effect on the coat colour. Only in dogs with two copies of a recessive allele d, the coat colour is diluted. Black dilutes into grey, also called blue or charcoal. The coat ranges from silver to almost black, but all have a blue nose. Chocolate/brown/liver dilutes into lilac/light tan/Isabella, their noses vary from pink, liver to isabella. Red/yellow/cream dilutes into champagne.
Coat colour is an intricate trait that involves a combination of multiple different genes. Testing for a range of different loci will give the most complete prediction of a dog's coat colour genetics.
Additional, undiscovered variants of the D-Locus mutation are likely to exist.
Pubmed ID: 32531980
Omia ID: 31