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Coat colour in dogs is controlled by a wide range of different genes working together.
10 working days
Beagle, Bull Terrier, Chow Chow, French Bulldog, Papillon, Sloughi, Staffordshire Bull Terrier, Thai Ridgeback
Swab, Blood EDTA, Blood Heparin, Semen, Tissue
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Coat colour in dogs is controlled by a wide range of different genes working together. These genes are often referred to as ‘loci’. The Dilution, or D-Locus, corresponds to the gene for melanophilin, MLPH, which is involved in the distribution of pigment. Mutations of the D-Locus result in a ‘dilution’ of dark coat colours, turning them lighter and more silvery.
Any combination of two mutant alleles will result in a diluted coat. This variant of the D-Locus mutation, designated as d^2, is found in dogs such as the Chow Chow, Sloughi and Thai Ridgeback.
Hair and nose colour are diluted, the eye colour lightens to amber. The allele D is dominant and does not have an effect on the coat colour. Only in dogs with two copies of a recessive allele d, the coat colour is diluted. Black dilutes into grey, also called blue or charcoal. The coat ranges from silver to almost black, but all have a blue nose. Chocolate/brown/liver dilutes into lilac/light tan/Isabella, their noses vary from pink, liver to isabella. Red/yellow/cream dilutes into champagne.
Coat colour is an intricate trait that involves a combination of multiple different genes. Testing for a range of different loci will give the most complete prediction of a dog's coat colour genetics.
Additional, undiscovered variants of the D-Locus mutation are likely to exist.
Pubmed ID: 29349785
Omia ID: 31