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Brown coat colour in dogs is usually the result of a mutation to the B-Locus (TYRP1).
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Year Published |
General information
Brown coat colour in dogs is usually the result of a mutation to the B-Locus (TYRP1). However, in some French Bulldogs, a brown colour – known as cocoa – is instead caused by a recessive mutation to the gene HPS3.
Clinical features
Affected dogs have a brown coat colour, referred to as cocoa, which is often slightly darker than the brown caused by B-Locus in adult dogs. Cocoa dogs may be born with blue eyes, though both coat and eye colour tend to darken into adulthood. Note that a dog can be affected by both the B-Locus and Cocoa mutations, resulting in a lighter brown colour.
Additional information
Coat colour is an intricate trait that involves a combination of multiple different genes. Testing for a range of different loci will give the most complete prediction of a dog's coat colour genetics.
In human patients with Hermansky-Pudlak Syndrome 3, caused by a mutation to the same gene, bleeding disorders and visual impairments have been identified. It has not been investigated whether this is also applicable for cocoa coloured dogs.
References
Pubmed ID: 32526956
Omia ID: 2275
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