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While leopard complex spotting (LP; an incompletely dominant mutation) produces a collection of unique depigmentation patterns in the horse, other loci are responsible for modification of the extent of white.
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Specifications
| Breeds | Appaloosa, British Spotted Pony, Falabella, Knabstrupper, Miniature Horse, Pony of the Americas |
|---|---|
| Gene | |
| Organ | |
| Specimen | Hair, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Dominant |
| Chromosome | 3 |
| Also known as | PATN1 |
| Year Published | 2016 |
General information
While leopard complex spotting (LP; an incompletely dominant mutation) produces a collection of unique depigmentation patterns in the horse, other loci are responsible for modification of the extent of white. Pattern-1 (PATN1) is one of the indicated genes with a major modifying effect of LP for patterning. Horses with the more extreme white patterns (termed leopard and few-spot) have a parent with the same level of patterning, making it a single dominant mode of inheritance. This modifier has been termed PATN1 for pattern-1 or the first LP pattern modifier.
PATN1 is caused by a dominant mutation to the gene RFWD3.
Clinical features
Horses with LP and PATN1 have a high amount of white patterning while horses with LP but without PATN1 have a low amount of white patterning.
Additional information
References
Pubmed ID: 26568529
Omia ID: