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Canine Leukocyte Adhesion Deficiency type III (CLAD) is a disorder of white blood cells and platelets that causes increased susceptibility to infections and bleeding tendencies.
10 working days
Specifications
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Gene | |
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specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
Mode of Inheritance | |
Chromosome | |
Also known as | |
Year Published |
General information
Canine Leukocyte Adhesion Deficiency type III (CLAD) is a disorder of white blood cells and platelets that causes increased susceptibility to infections and bleeding tendencies. A mutation in FERMT3 causes malfunctioning of white blood cells and platelets, which causes a response to an injury or infection to fail.
Clinical features
In dogs that suffer of Canine Leucocyte Adhesion Deficiency type III the healing capacities are impaired. The affected dogs show severe infections. They die early in life from multiple severe infections, even if treated with massive doses of antibiotics.
Additional information
References
Pubmed ID: 20126836
Omia ID: 1525