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Canine Leukocyte Adhesion Deficiency type III (CLAD) is a disorder of white blood cells and platelets that causes increased susceptibility to infections and bleeding tendencies.

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Specifications

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Canine Leukocyte Adhesion Deficiency type III (CLAD) is a disorder of white blood cells and platelets that causes increased susceptibility to infections and bleeding tendencies. A mutation in FERMT3 causes malfunctioning of white blood cells and platelets, which causes a response to an injury or infection to fail.

Clinical features

In dogs that suffer of Canine Leucocyte Adhesion Deficiency type III the healing capacities are impaired. The affected dogs show severe infections. They die early in life from multiple severe infections, even if treated with massive doses of antibiotics.

Additional information

References

Pubmed ID: 20126836

Omia ID: 1525

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