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H709

Canine leukocyte adhesion deficiency (CLAD) is a fatal immunodeficiency disease found in Irish setters.

10 working days

Specifications

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Canine leukocyte adhesion deficiency (CLAD) is a fatal immunodeficiency disease found in Irish setters. The disease is caused by a mutation in the ITGB2 gene, which encodes the leukocyte integrin beta-2 subunit (CD18). The mode of inheritance is autosomal recessive.

Clinical features

Clinical features include severe infections of omphalophlebitis, skin infections, osteomyelitis, gingivitis, fever, anorexia, lameness, impaired wound healing, severe skin infections, salivation, thickened mandible, enlarged metaphyses of the distal radius, ulna, tibia, fibula, lameness, enlarged lymph nodes, and low body weight. Untreated dogs often die by 6 months of age.

Additional information

References

Pubmed ID: 10512685

Omia ID: 595

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3. Results

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