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Canine leukocyte adhesion deficiency (CLAD) is a fatal immunodeficiency disease found in Irish setters.
10 working days
Swab, Blood EDTA, Blood Heparin, Semen, Tissue
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Canine leukocyte adhesion deficiency (CLAD) is a fatal immunodeficiency disease found in Irish setters. The disease is caused by a mutation in the ITGB2 gene, which encodes the leukocyte integrin beta-2 subunit (CD18). The mode of inheritance is autosomal recessive.
Clinical features include severe infections of omphalophlebitis, skin infections, osteomyelitis, gingivitis, fever, anorexia, lameness, impaired wound healing, severe skin infections, salivation, thickened mandible, enlarged metaphyses of the distal radius, ulna, tibia, fibula, lameness, enlarged lymph nodes, and low body weight. Untreated dogs often die by 6 months of age.
Pubmed ID: 10512685
Omia ID: 595