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Intervertebral disc disease (IVDD) is a degenerative condition.
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Specifications
General information
Intervertebral disc disease (IVDD) is a degenerative condition. The disease causes burstings into the spinal cord between the bones of the spinal column. The disorder is caused by a complex mutation, a FGF4 retrogene insertion, on chromosome 12.
Clinical features
Clinical features include abnormal walking, hunched back or neck with tense muscles, paralysis and reduced appetite and activity level.
Additional information
The occurrence of this genetic variant in some breeds is high but it is known that not all dogs that carry the 12-FGF4RG variant will develop IVDD and vice versa. This suggests that this variant is not ‘the whole story’ and there are almost certainly additional lifestyle and/or genetic risk factors for IVDD that remain to be identified.
References
Pubmed ID: 29073074
Omia ID: 157
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