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Dandy-Walker-like malformation (DWLM), a form of cerebellar hypoplasia, is a disorder caused by abnormal brain development, which in turn causes a lack of muscle coordination.
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Specifications
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specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
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General information
Dandy-Walker-like malformation (DWLM), a form of cerebellar hypoplasia, is a disorder caused by abnormal brain development, which in turn causes a lack of muscle coordination. DWLM in the Eurasier is caused by a recessive mutation to the gene VLDLR
Clinical features
Affected dogs begin to present symptoms when they start to walk. These symptoms include rolling and/or leaning, hypermetric gait (overstepping while walking), tremors, loss of menace response and other difficulties with perception.
Additional information
References
Pubmed ID: 25668033
Omia ID: 1947