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Cerebellar cortical degeneration (CCD) is a neurodegenerative disease process affecting many dog breeds.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Cerebellar cortical degeneration (CCD) is a neurodegenerative disease process affecting many dog breeds. The disease affects a specific area of the brain known as the cerebellum. In cerebellar degeneration, the cells within the cerebellum die, causing neurological symptoms in dogs.
This variant of the disorder, also known as Neonatal Cortical Cerebellar Degeneration (NCCD), is found in the Vizsla. It is caused by a recessive mutation to the gene SNX14.
Clinical features
The age of onset ranges from neonatal to early onset from weeks to months. Symptoms include walking abnormality, broad stance, swaying, muscle tremors with eating and performing activity, head tilt, loss of coordination and abnormal posture.
Additional information
References
Pubmed ID: 27566131
Omia ID: 2034
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