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H412

Canine Complement 3 (C3) deficiency is a metabolic disorder in the Brittany Spaniel that leaves affected dogs vulnerable to infections.

10 working days

Specifications

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Year Published

General information

Canine Complement 3 (C3) deficiency is a metabolic disorder in the Brittany Spaniel that leaves affected dogs vulnerable to infections. It is caused by a recessive mutation to the C3 gene.

Clinical features

Particularly when young, affected dogs are likely to experience recurrent bacterial infections such as pneumonia, urinary tract infections and uterine tract infections. They are also more prone to Membranoproliferative Glomerulonephritis (MPGN), which can cause kidney damage and failure.

Additional information

References

Pubmed ID: 9510185

Omia ID: 155

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