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Canine Complement 3 (C3) deficiency is a metabolic disorder in the Brittany Spaniel that leaves affected dogs vulnerable to infections.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Canine Complement 3 (C3) deficiency is a metabolic disorder in the Brittany Spaniel that leaves affected dogs vulnerable to infections. The disorder is caused by a recessive mutation to the C3 gene.
Clinical features
Affected dogs are vulnerable to to various kidney and urinary tract diseases. Particularly when young, they are likely to experience recurrent bacterial infections such as pneumonia, urinary tract infections and uterine tract infections. They are also more prone to Membranoproliferative Glomerulonephritis (MPGN), which can cause kidney damage and kidney failure.
Additional information
References
Pubmed ID: 9510185
Omia ID: 155