Some tests are breed dependent because not all breeds share the same genetic background, this means that some mutations do occur in certain breeds and some do not.
Validation of a test for a certain breed is based on:
- Scientific publications: Scientists link variation in DNA to disorders or traits. A mutation is recognised by comparing the symptoms of a disorder or trait with variation in the DNA. This normally leads to publication in scientific articles. Often these articles are based on a single or only a few breeds.
- Other breeds: Mutations described and validated in one breed can also occur in other breeds. Laboratories and scientists recognise this, but often do not publish this in scientific articles.
If the result of a DNA test indicates that an animal is no carrier of a certain mutation, this is no guarantee that this animal will never develop the disorder or the characteristic. Some disorders can also be caused without a genetic component and the existence of unknown mutations can never be ruled out.
When the result of a DNA test indicates that an animal is affected (or carrier in case of dominant mutations) of a mutation, this is normally the basis for assuming that an animal will develop the disease or trait.
The person requesting the DNA test is responsible for the decision whether he / she wants to have a test carried out based on above information.
