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H389

Alexander Disease (AxD) is a severe, progressive neural disorder that results in loss of coordination, weak movement and ultimately death.

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Specifications

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Also known as

Year Published

General information

Alexander Disease (AxD) is a severe, progressive neural disorder that results in loss of coordination, weak movement and ultimately death. AxD in the Labrador Retriever is caused by a dominant mutation to the gene GFAP.

Clinical features

Symptoms of AxD generally start in dogs under one year of age. Early signs can include a loss of coordination and balance, a head tilt, "knuckled" paws and an aversion to touch. The disease progresses to weakened limbs, and can also cause muscle atrophy and stiffness, regular jerks of the head and limbs, difficulty eating and an altered voice. AxD is ultimately fatal.

Additional information

References

Pubmed ID: 26486469

Omia ID: 1208

How does it work?

1. Select your product(s)

Select your single test, a CombiBreed Package or create your own Bundle.

2. Collect DNA sample

Collect DNA material as indicated with our products and send it to our laboratory.

3. Results

We handle your DNA sample with care and provide you with the results.

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