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H389

In dogs with Alexander disease (GFAP) astrocytes, which are supportive cells of the central nervous system are malfunctioning.

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Specifications

Breeds

Gene

Organ

specimen

Swab, Blood EDTA, Blood Heparin, Semen, Tissue

Mode of Inheritance

Chromosome

Year Published

General information

In dogs with Alexander disease (GFAP) astrocytes, which are supportive cells of the central nervous system are malfunctioning. This causes neurodegenerative disorders.

Clinical features

Dogs with Alexander disease display symptoms within a few hours to a maximum of several weeks after birth. The puppies are weak or almost paralyzed. They can show spastic front limbs which is known as “swimming puppy syndrome”.

Additional information

References

Pubmed ID: 26486469

Omia ID: 1208

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