€0,- €0,- excl. VAT
Only available in bundles
Early Adult Onset Deafness (EAOD) is a hearing disorder in Border Collies.
10 working days
From €5,95 shipping and administration per order (incl. VAT)
Only available in bundles
Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Early Adult Onset Deafness (EAOD) is a hearing disorder in Border Collies. While age-related hearing loss typically begins around 8–10 years, EAOD has an early onset at 3–5 years. For working Border Collies, EAOD is particularly problematic, as even slight differences in tone perception are essential for their ability to perform tasks. Therefore, even moderate hearing loss can significantly impact their working ability, though it does not have other serious (medical) consequences.
We test four genetic variants that are risk factors for progressive deafness in Border Collies. These variants are found in three genes: the USP31 gene, which is involved in mitigating tissue damage in the ear, the HS3ST2 gene, which may play a role in brain function and the RBBP6 gene, which plays an important role in ear development.
Clinical features
Gradual hearing loss is observed in dogs between the ages of 3 and 5 years, affecting both ears. You may notice the following signs and behavioural changes in your dog: changes in sleep patterns, changes in barking, increased startle responses to environmental factors, disobedience and/or fewer greetings.
Additional information
These tested are based on an association study in which multiple DNA variants near the USP31 gene on chromosome 6 were discovered. These variants have been linked to Early Adult Onset Deafness (EAOD) in Border Collies. Each DNA variant is considered a "risk factor". VHLGenetics tests only the four variants that have been published as having the "highest risk."
This test is particularly beneficial for breeders whose dogs have a history of deafness in their pedigree, as it can assist in making informed breeding decisions. If the test results indicate that a dog is a carrier or affected for any of the four variants, it suggests an increased risk of developing EAOD. However, the exact level of risk associated with these variants is not yet known. If your dog's test results show a carrier or affected status, this information can be used to ensure that the dog is bred only with a mate that is clear of these variants.
References
Pubmed ID: 23028339
Omia ID: 2550