€0,- €0,- excl. VAT
Only available in bundles
Polymyositis is a muscle disease in which inflammation of the muscles leads to problems with walking and swallowing.
10 working days
From €5,95 shipping and administration per order (incl. VAT)
Only available in bundles
Specifications
| Breeds | |
|---|---|
| Gene | |
| Mutation | unpublished |
| Organ | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Risk Factor |
| Also known as | PM |
General information
Polymyositis is a muscle disease in which inflammation of the muscles leads to problems with walking and swallowing. This variant has been identified in the Dutch Kooikerhondje. Two DNA mutations are involved in the development of polymyositis in this breed: PM1 and PM2. Only dogs that are homozygous or heterozygous for PM1 develop the disease.
Dogs that are homozygous for the PM1 mutation have approximately a 10% chance of developing the disease, while dogs that are heterozygous for the PM1 mutation have up to 2% chance of developing the disease.
If these dogs are also homozygous or heterozygous for PM2, the risk of developing the disease increases by 30%.
Clinical features
The average age at which symptoms first appear is 3 years for dogs that are homozygous for the PM1 mutation and approximately 4.5 years for dogs that are heterozygous for the PM1 mutation.
The most noticeable symptoms are muscle pain, abnormal gait, general muscle weakness, and muscle stiffness. Swallowing difficulties may occur. In addition, as the disease progresses, symptoms such as lethargy, weight loss, reduced endurance, and breathing problems may develop due to development of aspiration pneumonia.
Additional information
This DNA test is performed in collaboration with the Expert Centre for Veterinary Genetics of Utrecht University.
It is important to test for PM2 if your dog is heterozygous or homozygous for the PM1 mutation in order to determine the additional risk of developing the disease.
It is also important to test for PM2 in dogs without the PM1 mutation if there are plans to breed the dog with a PM1 heterozygous dog. Breeding with PM1 homozygous dogs is discouraged.
Explanation of results WW = Your Kooikerhondje is free of the second risk factor for polymyositis (PM2). (Note: If your dog is heterozygous or homozygous for PM1, your dog may still be at risk to develop polymyositis.)
WM = Your Kooikerhondje is heterozygous for the second risk factor for polymyositis (PM2). (Note: If your dog is free of PM1, there is no risk of polymyositis. If your dog is heterozygous or homozygous for PM1, your dog has an increased risk of developing polymyositis. It is recommended to carefully monitor your dog for clinical signs.)
MM = Your Kooikerhondje is homozygous for the second risk factor for polymyositis (PM2). (Note: If your dog is free of PM1, there is no risk of polymyositis. If your dog is heterozygous or homozygous for PM1, your dog has an increased risk of developing polymyositis. It is recommended to carefully monitor your dog for clinical signs.)
References
Pubmed ID: unpublished
Year published:
Omia ID: 1874
Omia variant ID: