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Coat colour in dogs is controlled by a wide range of different genes working together.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Chromosome | 11 |
| Mutation | c.555T>G |
| Organ | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | B-Locus |
General information
Coat colour in dogs is controlled by a wide range of different genes working together. These genes are often referred to as ‘loci’. The Brown, or B-Locus, corresponds to the gene ‘tyrosinase-related protein 1’ (TYRP1), which controls the production of black pigment. Several different recessive mutations can result in a lightening of the dog’s coat from black to brown. The mutation analysed in this particular test occurs specifically in the Australian Shepherd.
Clinical features
Affected dogs that would otherwise have a black coat develop a brown coat instead. If the dog is also affected by the D-Locus mutation, the dog will be lilac or isabella.
Additional information
Coat colour is an intricate trait that involves a combination of multiple different genes. Testing for a range of different loci will give the most complete prediction of a dog's coat colour genetics.
References
Pubmed ID: 28497851
Year published: 2017
Omia ID: 1249
Omia variant ID: