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Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs. Caused by an X-linked recessive mutation to the gene F8, the disease strongly impairs the blood’s ability to clot, which can lead to severe symptoms such as spontaneous internal bleeding, or uncontrolled bleeding after injury or surgery. This specific variant of the disease occurs in the Rhodesian Ridgeback. Related variants are also found in the Irish Setter and Miniature Schnauzer, Boxer, Old English Sheepdog, and the German Shepherd.
Clinical features
Common clinical signs in dogs included: bleeding from the mouth, subcutaneous and intramuscular haematomas and lameness.
Additional information
References
Pubmed ID: 33494213
Omia ID: 437