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Autoimmune Lymphoproliferative Syndrome (ALPS) or Feline Autoimmune Lymphoproliferative Syndrome (FALPS) is a rare autosomal dominant disease in British Shorthair cats and related breeds that is caused by a mutation in the FASL gene.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Autoimmune Lymphoproliferative Syndrome (ALPS) or Feline Autoimmune Lymphoproliferative Syndrome (FALPS) is a rare autosomal dominant disease in British Shorthair cats and related breeds that is caused by a mutation in the FASL gene. ALPS is characterized by an accumulation of immune cells in lymph nodes and spleen, causing enlargement of these tissues. The disease is fatal within weeks, with affected kittens either dying or being euthanized.
Clinical features
Kittens with ALPS start showing symptoms at around 6-8 weeks of age. Affected kittens develop enlarged lymphnodes, enlarged spleen and can also display swelling of the abdomen, anaemia, lethargy, and weight loss.
Additional information
References
Pubmed ID: 27770190
Omia ID: 2064