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Cyclic Neutropenia is a stem cell disease, which is characterised by cyclic fluctuations in leukocyte numbers, especially the neutrophils.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Cyclic Neutropenia is a stem cell disease, which is characterised by cyclic fluctuations in leukocyte numbers, especially the neutrophils.
In dogs the disease is also known as cyclic hematopoiesis or Grey/Gray Collie Syndrom. In humans known as Hermansky-Pudlak Syndrome 2 (HPS-2).
Clinical features
Affected animals have an associated coat colour dilution, causing a gray coat colour. The cyclic neutropenia is associated with symptoms as recurrent fever, anorexia and severe - often life threathening - infections.
Additional information
References
Pubmed ID: 12897784
Omia ID: 248