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Malignant Hyperthermia (MH) is a disorder that affects skeletal muscle function during anaesthesia.
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Specifications
| Breeds | Smooth Collie, Doberman, German Shepherd, Labrador Retriever, Rough Collie |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Malignant Hyperthermia (MH) is a disorder that affects skeletal muscle function during anaesthesia. It typically remains unnoticed unless triggered, most often by certain anesthetic drugs. When activated, it can cause a rapid and severe reaction involving abnormal muscle activity and dangerously accelerated metabolism. MH is caused by a mutation in the RYR1 gene and is inherited in an autosomal dominant manner. This mutation has been identified in several breeds, including Doberman, Labrador Retriever, Rough Collie, Smooth Collie and German Shepherd.
Clinical features
Dogs with MH generally appear completely healthy until exposed to a triggering factor, such as specific anesthetic agents. When triggered, symptoms may develop within minutes and include extremely high body temperature, muscle stiffness, rapid breathing, irregular heart rhythm, and collapse. The reaction is rapid and can be life-threatening without the immediate discontinuation of the anesthetic and emergency care. MH can occur at any age, but clinical signs are most often seen during surgical procedures involving general anesthesia.
Additional information
References
Pubmed ID: 11575546, 15474681
Omia ID: 621