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Canine Leukocyte Adhesion Deficiency (CLAD) is a fatal immunodeficiency disease.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
General information
Canine Leukocyte Adhesion Deficiency (CLAD) is a fatal immunodeficiency disease. It is a genetic condition caused by specific mutations in genes crucial for platelet and blood cell functions. These mutations result in abnormal blood clotting and immune system responses in affected dogs. This variant of the disease, CLAD Type I, is caused by a recessive mutation in the ITGB2 gene, which encodes the leukocyte integrin beta-2 subunit (CD18). The disease is found in the Irish Setter.
Clinical features
Irish Setter puppies may exhibit umbilical vein infection (omphalophlebitis), swollen or inflamed lymph nodes (generalized lymphadenopathy), impaired wound healing and anorexia. Dogs may also display various other symptoms, including lameness, recurrent skin infections, osteomyelitis (bone infections) and gingivitis. While some dogs can live with this condition, most affected dogs die prematurely by 6 months of age due to severe infections, bleeding from injuries, or complications during surgical procedures.
Additional information
References
Pubmed ID: 10512685
Omia ID: 595