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Glanzmann’s Thrombasthenia (GT) is a bleeding disorder caused by defective platelets, which can result in uncontrolled bleeding.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Year Published |
General information
Glanzmann’s Thrombasthenia (GT) is a bleeding disorder caused by defective platelets, which can result in uncontrolled bleeding. This variant of the disease, Type I Glanzmann’s Thrombasthenia, is caused by a recessive mutation to the gene ITGA2B. It is observed in the Great Pyrenees. A related variant is found in the Scottish Deerhound.
Clinical features
Affected dogs are susceptible to excessive bleeding, such as nosebleeds or bleeding from the gums during tooth eruption. Blood analysis will show normal platelet counts but minimal platelet activity.
Additional information
References
Pubmed ID: 11105947
Omia ID: 1000