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Congenital myasthenic syndrome (CMS) is a hereditary neuromuscular disorder characterised by severe generalized skeletal muscle weakness and fatigue, usually it manifests itself with exertion.
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Specifications
| Breeds | |
|---|---|
| Gene | |
| Chromosome | 28 |
| Mutation | c.85G>A |
| Organ | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal Recessive |
| Also known as | CMS |
General information
Congenital myasthenic syndrome (CMS) is a hereditary neuromuscular disorder characterised by severe generalized skeletal muscle weakness and fatigue, usually it manifests itself with exertion.
Clinical features
Affected dogs are able to run normally for 5–30 min after which they take shorter and shorter strides and eventually fall down with flexed fore- and hindlegs. After some minutes rest, they are able to walk and run again for variable periods of time before the signs reappear.
Additional information
References
Pubmed ID: 17586598
Year published: 2007
Omia ID: 2072
Omia variant ID: